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Antihistamines are not recommended for the treatment of sinusitis in the absence of known allergic disease, because they cause further thickening of secretions (Willett, 1994) Antibiotics The controversy around use of antibiotics in sinusitisNov 06, 19 · Yes Overthecounter (OTC) pain relievers and decongestants may help relieve facial pain and sinus congestion associated with acute sinusitis OTC medications that may help include Decongestants These work by narrowing blood vessels to help reduce inflammation and swelling that cause sinus congestion Such OTC medicationsJan 25,  · Antibiotics If your doctor thinks a bacterial infection is to blame, they may prescribe antibiotics For acute sinusitis, you typically take them for 1014 days What To Do When You Have A Sinus Infection Consumer Reports How to treat sinus infection antibiotics